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KMID : 0385020040200020128
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Korean Journal of Laboratory Animal Science
2004 Volume.20 No. 2 p.128 ~ p.133
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A Comparative Study of Exocrine Pancreas in Male and Female Rats
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Park Hyung-Seo
Kim Se-Hun
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Abstract
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Cellular amylase contents, spontaneous amylase secretion, and cholecystokinin (CCK)-induced amylase secretion were compared from the male and female rats using the isolated pancreatic lobules. Estrous stages of female rats were characterized by vaginal smears. To stimulate amylase secretion, CCK (100 pM) was added to incubation medium. Cellular amylase contents of male pancreatic lobule were similar to that found in female pancreatic lobules at diestrus and estrus. Spontaneous pancreatic amylase secretion of male rats was higher compared to female rats at estrus, but not different from female rats at diestrus. cholecystokinin markedly stimulated pancreatic amylase secretion, dosedependently. However, CCK-induced pancreatic amylase secretion of male rat was not different from female rat at estrus and diestrus. We conclude from the above results that pancreatic amylase synthesis was not different according to sex, and that spontaneous pancreatic amylase secretion was lower in female rat at estrus. However, These differences were thought to be masked by more potent stimulants in pancreatic amylase secretion.
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KEYWORD
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Exocrine pancreas, Amylase, Estrous cycle, Cholecystokinin, Sex difference
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